Category/Topic
Health and Nutrition
State or Federal?
Federal
Summary
The National Institute of Neurological Disorders and Stroke (NINDS) and National Institute on Aging (NIA) intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for a large prospective clinical research study to determine the specific subsets of stroke events that predict cognitive impairment and dementia in post-stroke populations in the United States, including in health disparities populations, and what additional clinical factors and comorbidities along the Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) spectrum may causally synergize with stroke to result in (or prevent) cognitive impairment and dementia outcomes. The goals of this initiative are to determine the association between specific subsets of stroke events and subsequent cognitive impairment and dementia in post-stroke populations in the United States, including in health disparities populations; to identify additional clinical factors and comorbidities that may affect these associations; and to contribute to development and validation of clinical-trial ready diagnostic and progression biomarkers for post-stroke dementia. It is expected that the study design will also allow for determination of interrelationships (cross-sectional and longitudinal) among the stroke event, overall cerebrovascular and cardiovascular disease and risk factors (including sex, racial, and ethnic differences), dementia-relevant genetic variants (including ApoE) and mutations (e.g. in Notch 3) previously associated with Alzheimer's disease (e.g. APP, PS1, PS2, PICALM, CLU, TREM2), cognitive trajectories including decline and resistance to decline, as well as amyloid and tau biomarkers of Alzheimers pathology during life.
Eligible Entities
Academic Institutions, K-12 School Districts, Local Public Agencies, Native American Tribes, Nonprofit Organizations, Private Corporations, State Government
Eligibility Notes
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

Hispanic-serving Institutions
Historically Black Colleges and Universities (HBCUs)
Tribally Controlled Colleges and Universities (TCCUs)
Alaska Native and Native Hawaiian Serving Institutions
Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Most Recent/Current Due Date
Apr 17, 2019
Most Recent RFP Release Date
Feb 15, 2019
Max Award
$39,000,000
Total Possible Multi-Year Award
$39,000,000
# of Awards
1
Annual or Multi-Year?
Multi-year
Match Required?
No
Funder
Department of Health and Human Services
Total Amount Available for All Grants
$9,750,000
Competition Notes
NIH intends to commit $9,750,000 total costs in FY 2019 to fund 1 award. Budgets are limited to $39,000,000 in Direct Costs over the total project period. The maximum project period is 6 years.
Further Information

Link to Further Information
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